Fabrication, drug delivery kinetics and cell viability assay of PLGA-coated vancomycin-loaded silicate porous microspheres

Porous ceramic microspheres are a desirable substance for bone tissue reconstruction and delivery applications. This study focuses on Mg–Ca silicate encapsulated in biodegradable poly (lactic-co-glycolic acid) (PLGA) to serve as biocompatible carrier the controlled release of vancomycin hydrochloride. In this regard, diopside (MgCaSi 2 O 6 ), bredigite (MgCa 7 Si 4 16 akermanite ) powders were synthesized by sol-gel subsequent calcination methods. Then, porous akermanite, 700–1000 μm diameter fabricated using carbon porogen, droplet extrusion sintering, then loaded with drug eventually coated PLGA. The bare showed considerable burst mode into physiological medium, whereas PLGA coating reduced level. To investigate effective mechanisms governing from carriers, contribution burst, degradation, diffusion was analyzed sequential quadratic programming algorithm method. It found that relative bioresorption is ranked > bredigite, dominates mechanism. dental pulp stem cells cytocompatibility MTT assay also loading deteriorates but improves cell biocompatibility significantly. Comparatively, PLGA-coated result compromise between constituting ions carriers molecules. concluded promising candidates drug-delivery engineering grafting